Clinical Evidence
Through continuous clinical studies and innovative
technologies, Handokhealthcare’ products continue to prove
its benefits across multiple applications.
Arthritis
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Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study.
Knee Osteoarthritis
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The Oral Administration of Highly-Bioavailable Curcumin for One Year Has Clinical and Chondro-Protective Effects: A Randomized, Double-Blinded, Placebo-Controlled Prospective Study.
Knee Osteoarthritis
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Short-term Effectiveness of Nexala® in the Treatment of Patients with Gonarthrosis and Coxarthrosis.
Knee Osteoarthritis
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The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study.
Knee Osteoarthritis
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Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis.
Knee Osteoarthritis
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Bioavailability
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Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects.
Bioavailability
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Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study
Bioavailability
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Drinkable preparation of Theracurmin exhibits high absorption efficiency–a single-dose, double-blind, 4-way crossover study.
Bioavailability
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Innovative preparation of curcumin for improved oral bioavailability.
Bioavailability
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Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants
Bioavailability
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Brain
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Theracurmin Supplementation May be a Therapeutic Option for Older Patients with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up Study.
Cognitive Function
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Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.
Cognitive Function
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The Effect of Theracurmin on Cognitive Function in an Older Patient with Chemobrain.
Cognitive Function
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The effects of curcumin on Brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study.
Schizophrenia
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The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients.
Migraine
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Improvement in autonomic balance through 12-week supplementation of a novel curcumin formulation in healthy Japanese adults: A randomized, placebo-controlled studySafety evaluation of high bioavailability curcumin in Healthy Japanese Adults: A Randomized, placebo-controlled study
Mood
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Cancer
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A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.
Pancreatic Cancer/ Biliary Tract Cancer
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Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response.
Esophageal Adenocarcinoma
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Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest.
Prostate & Bladder Cancer
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Therapeutic applications of curcumin for patients with pancreatic cancer.
Pancreatic Cancer
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Cardiovascular System
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Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
Vascular Endothelial Function
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Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise.
Endothelial Function
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Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.
Central Arterial Hemodynamics
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Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women.
Cardiovascular System
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Liver
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Effects of a Health Drink Containing the Extract of the Hovenia Dulcis Fruit Stalk andTheracurmin, on Ethanol-Induced Hangover.
Liver
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Effects of Theracurmin® consumption on liver function, fatigue, and sleep: a randomized, double-blind, placebo-controlled, parallel-comparison study.
Liver Function (ALT)
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Muscle
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Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.
Muscle Recovery
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Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men.
Muscle
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Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation.
Muscle
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Respiratory System
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Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study
Respiratory System
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Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.
Respiratory System
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Review
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Clinical Application of “Curcumin”, a Multi-Functional Substance.
Theracurmin®
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Novel Curcumin Oral Delivery Systems.
Theracurmin®
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Therapeutic applications of curcumin for patients with pancreatic cancer.
Pancreatic Cancer
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Highly bioavailable curcumin (Theracurmin): its development and clinical application.
Theracurmin®
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Tolerability
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Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.
Tolerability
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Safety evaluation of high bioavailability curcumin in Healthy Japanese Adults: A Randomized, placebo-controlled, double-blind, parallel-group comparison study
Tolerability
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Safety Evaluation of Theracurmin® in Healthy Japanese Adults. ―A Randomized, Double-blind, Placebo-controlled Parallel-group Study―
Tolerability
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